LOX-1 in Ischemic Stroke

LOX-1, an OLR1 gene product, has been found to be the receptor for oxidized low density lipoprotein (LDL) to induce endothelial dysfunction. Animal studies suggested that LOX-1 promotes atherosclerosis, aggravates myocardial infarction, and enhances restenosis. Although researchers have mainly focused on coronary artery disease, reports on ischemic stroke are gradually accumulating. In parallel, more human epidemiological and clinical studies are being reported. Here we describe ligands and the receptor LOX-1 separately to clarify the current status.